Based on the domestic and foreign experience in the hazardous waste classification management and the traditional health risk assessment steps, this paper proposed a refineddynamic health risk assessment method to classify the hazardous waste which is aligned with the traditional health risk assessment steps. But in this method, we first considered the calculation of pollutant release from hazardous waste and the influence of enterprise management level and utilization/disposal processes on the pollutant release probability and amount. Then, the health risk was quantitatively assessed based on the migration and transformation of pollutants in the environmental media and the exposureresponse relationship. According to the pollution characteristics database and accident scenario database of hazardous waste, combined with the information collection technology of the whole process, the classification and classification management platform of hazardous waste is built to classify the risk levels of wasterelated enterprises, implement differentiated management, and form a more scientific and effective refined management system of the whole process of hazardous waste.