In recent years, the problem of unstable monthly water quality in Hualin section of the Weihe River in Gansu has attracted extensive attention from the management department. Understanding the current situation of nonpoint source pollution in the watershed of Hualin section of the Weihe River in Gansu is important to control the nonpoint source pollution and to promote the water quality to meet the standard. This paper used the DPeRS (Diffuse Pollution estimation with Remote Sensing) nonpoint source pollution assessment model to analyze the spatial distribution characteristics of nonpoint source pollution in the watershed of Hualin section of the Yellow River Basin in Gansu in 2018, including analysis on production and discharge characteristics of multitype pollution amount. The results showed as follows: in 2018, nonpoint source pollution discharge loads of total nitrogen (TN), total phosphorus (TP), ammonia nitrogen (NH₄⁺-N), and dichromate index (COD_Cr) in the watershed of Hualin section in Gansu were 11 591, 2 697, 7 141 and 1 458 t, and the amount of pollutants entering into river were 2 183 t, 512 t, 1 347 t, and 263 t, respectively; in terms of spatial distribution, the highvalue areas of nitrogentype (TN and NH₄⁺-N) discharge loads mainly distributed in sections of Longxi County, Wushan County and Minxian County. The TP emissions from nonpoint source varied greatly among different countylevel administrative districts, and theTP discharge load in Wushan County was more prominent; the COD_Cr emissions in sections of Longxi County, Weiyuan County and Wushan County were more prominent. There were significant differences in the spatial distribution of nonpoint source pollution discharge load in the watershed. The high load areas of nitrogen and phosphorus type (TN, NH₄⁺-N and TP) mainly distributed in Wushan County, Longxi County and Lintao County. High load area of COD_Cr type nonpoint source pollution showed a scattered distribution. The soil erosion in the west of Zhangxian County causes high sand load of west Zhangxian County, Longxi County and north Weiyuan County. Pollution control in dry season is still the key period to ensure stable water quality. Farmland surface runoff is the primary pollution type of nitrogen and phosphorus nonpoint source pollution in the catchment area of Hualin section of Weihe River in Gansu Province, and livestock and poultry breeding is the primary pollution type of COD_Crtype nonpoint source pollution.