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| 摘要: |
| 建立了固相萃取-液质联用分析药物和个人护理品（PPCP<sup>s</sup>）的方法，采用Oasis HLB固相萃取柱分别在酸性条件下和碱性条件下对PPCP<sup>s</sup>进行富集提取，该法对于宜兴地区能够检出的30种PPCP<sup>s</sup>均具有良好的线性，相关系数为0.990~0.999，检出限为1.37~10.12ng/L。应用该法对宜兴地区地表水中存在的PPCP<sup>s</sup>进行分析，结果显示30种PPCPs均有不同程度检出，分布最广泛的7种分别为避蚊胺、阿替洛尔、对乙酰氨基酚、普鲁卡因、β-雌二醇、卡马西平和苯佐卡因，阿替洛尔浓度较高，普遍为5~600ng/L。避蚊胺虽然出现频率最高，但其在各个采样点浓度偏低，普遍为1~50 ng/L。 |
| 关键词: 药物 个人护理品 宜兴 固相萃取-液质联用 |
| DOI： |
| 分类号:X832；O657.63 |
| 文献标识码:B |
| 基金项目: |
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| Determination of Pharmaceutical and Personal Care Products by Solid Phase Extraction Coupled with LC/MS |
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ZENG Chao， JIANG Ke wei， QIAN Jia， ZHOU Ji tang， LIU Min min
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| Abstract: |
| A method for determination of pharmaceutical and personal care products （PPCP<sup>s</sup>） was developed using solid phase extraction liquid chromatography/mass spectrometry （SPE LC/MS）. The PPCP<sup>s</sup> were concentrated by Oasis HLB solid phase extraction column at acidic and alkaline conditions. Thirty PPCP<sup>s</sup> were detected in Yixing City by the developed method with the correlation coefficient in the range of 0.990~0.999 and the detection limit in the range of 1.37~10.12 ng/L. The most frequently detected PPCP<sup>s</sup> were diethyltoluamede， atenolol， paracetamol， procaine， beta estradiol， carbamazepine and benzocaine. Atenolol had the highest concentration of these PPCP<sup>s</sup> with the range of 500~600 ng/L. Diethyltoluamede was the most frequently discovered PPCPs ， however， the concentrations were low with the range of 1~50 ng/L |
| Key words: Pharmaceuticals Personal care Yixing City SPE LC/MS |
