A method for the determination of 18 polychlorinated biphenyls （PCBs） in marine sediment was developed by QuEChERS coupled with gas chromatographytandem mass spectrometry. Sediment samples were extracted with acetonitrile and cleaned up with PSA and C18 adsorbent powder. The analytes were then detected by multiple reaction monitoring （MRM） modes. The results showed that， the linear relationships of the 18 PCBs were good with the correlation coefficients ranged from 0.999 2 to 0.999 9. The average recoveries of the target compounds in marine sediments collected from adjacent sea of Lianyungang spiked at three different concentrations ranged from 70.6% to 96.5%， and the relative standard deviations ranged from 6.5% to 14.8%. The limits of detections for the target compounds were in the range of 0.02~0.08 μg/kg. It proved that， the developed method can avoid the use of large amounts of solvents， and is simple，stable，reliable and sensitive. It has been successfully applied to the analysis of trace PCBs in marine sediments.