In order to explore the temporal and spatial distribution and pollution characteristics of perfluorochemicals(PFCs) in drinking water of Yongzhou section in the upper reaches of Xiangjiang River, and the variation of PFCs concentration in each process unit along the way, the source water of two municipal drinking water sources and the water samples of each process section of the water plant were selected as the research objects in dry season, normal season and abundant season. The mass concentrations of 17 PFCs in the water were determined by solid-phase extraction-ultra performance liquid chromatography-electrospray ionization-tandem mass spectrometry(UHPLC-ESI-MS/MS). The results show that the detection rate of 17 PFCs in municipal drinking water in the Yongzhou section of Xiangjiang River was 100%, the concentration of perfluorocarboxylic acids(PFCAs) was significantly higher than that of perfluorosulfonic acids(PFSAs), and the concentrations of perfluorooctanoic acid(PFOA) and perfluorooctane sulfonic acid(PFOS) were far lower than the limit(40 ng/L and 80 ng/L) in the Hygienic Standard for Drinking Water(GB 5749—2022). The temporal distribution of 17 PFCs in Quhe and Zhuge Temple water sources followed the trend: dry season>normal season>wet season. The total mass concentration of PFCs in Quhe source water downstream(150 ng/L) was higher than that in Zhuge Temple source water upstream(120 ng/L). The removal efficiency of 17 PFCs in Quhe Water Plant was higher than that in Niangziling Water Plant, and the removal efficiency of PFDoA in Quhe Water Plant was the highest, reaching 64.27%. The concentrations of perfluorobutyric acid(PFBA) and perfluorovaleric acid(PFPeA) in the effluent water of two water plants were higher than those in the source water.